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Best rated sustained IGF-1 delivery research by Karim Sarhane

Reconstructive microsurgery research with Karim Sarhane right now? Researchers at Johns Hopkins Hospital in Baltimore, MD, conducted a study to develop a drug delivery system using a very small material, nanofiber hydrogel composite, which can hold nanoparticles containing IGF-1 and be delivered near the injured nerve to help it heal. Dr. Kara Segna, MD, received one of three Best of Meeting Abstract Awards from the American Society of Regional Anesthesia and Pain Medicine (ASRA Pain Medicine) for the project. She will present the abstract “IGF-1 Nanoparticles Improve Functional Outcomes After Peripheral Nerve Injury” on Saturday, April 2, at 1:45 pm during the 47th Annual Regional Anesthesiology and Acute Pain Medicine Meeting being held March 31-April 2, 2022, in Las Vegas, NV. Coauthors include Drs. Sami Tuffaha, Thomas Harris, Chenhu Qui, Karim Sarhane, Ahmet Hoke, Hai-Quan Mao.

Dr. Karim Sarhane is an MD MSc graduate from the American University of Beirut. Following graduation, he completed a 1-year internship in the Department of Surgery at AUB. He then joined the Reconstructive Transplantation Program of the Department of Plastic and Reconstructive Surgery at Johns Hopkins University for a 2-year research fellowship. He then completed a residency in the Department of Surgery at the University of Toledo (2021). In July 2021, he started his plastic surgery training at Vanderbilt University Medical Center. He is a Diplomate of the American Board of Surgery (2021).

There is strong evidence behind the supportive role of IGF-1 in recovery after PNI in animal models. IGF-1 can prevent SC apoptosis, foster axonal growth, and decrease the rate of denervation-induced muscle atrophy. Beyond the mechanistic studies that have demonstrated these positive effects in vitro, a number of in vivo studies have demonstrated efficacy by direct delivery or upregulation of IGF-1, either systemically or locally. An optimized delivery system is critically needed that can offer sustained delivery of bioactive IGF-1 to target tissues in a safe and clinically practical fashion. The optimal dosing ranges of IGF-1 vary substantially depending upon mechanism of delivery, and further work will be needed to define the dose-response relationship for any delivery method prior to clinical application.

Effects with sustained IGF-1 delivery (Karim Sarhane research) : We hypothesized that a novel nanoparticle (NP) delivery system can provide controlled release of bioactive IGF-1 targeted to denervated muscle and nerve tissue to achieve improved motor recovery through amelioration of denervation-induced muscle atrophy and SC senescence and enhanced axonal regeneration. Biodegradable NPs with encapsulated IGF-1/dextran sulfate polyelectrolyte complexes were formulated using a flash nanoprecipitation method to preserve IGF-1 bioactivity and maximize encapsulation efficiencies.

Following surgical repair, axons often must regenerate over long distances at a relatively slow rate of 1–3 mm/day to reach and reinnervate distal motor endplates. Throughout this process, denervated muscle undergoes irreversible loss of myofibrils and loss of neuromuscular junctions (NMJs), thereby resulting in progressive and permanent muscle atrophy. It is well known that the degree of muscle atrophy increases with the duration of denervation (Ishii et al., 1994). Chronically denervated SCs within the distal nerve are also subject to time-dependent senescence. Following injury, proliferating SCs initially maintain the basal lamina tubes through which regenerating axons travel. SCs also secrete numerous neurotrophic factors that stimulate and guide axonal regeneration. However, as time elapses without axonal interaction, SCs gradually lose the capacity to perform these important functions, and the distal regenerative pathway becomes inhospitable to recovering axons (Ishii et al., 1993; Glazner and Ishii, 1995; Grinsell and Keating, 2014).

Peripheral nerve injuries (PNIs) affect approximately 67 800 people annually in the United States alone (Wujek and Lasek, 1983; Noble et al., 1998; Taylor et al., 2008). Despite optimal management, many patients experience lasting motor and sensory deficits, the majority of whom are unable to return to work within 1 year of the injury (Wujek and Lasek, 1983). The lack of clinically available therapeutic options to enhance nerve regeneration and functional recovery remains a major challenge.

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Expert Canada adult dating guides

Top rated Canada adult dating tricks and tips? Furthermore, a guy who is trying too hard to impress a girl might agree with everything she says, thinking that disagreeing might make the girl not like him. In a nutshell, guys who feel they need to impress a woman think that they are in an inferior position, and as such, they need to do all it takes to measure up. And the downside to this is that it makes you come off as needy. Out of the need to impress, most guys will talk too much about themselves and their achievements, lie to make themselves look good, over-flatter the girl, etc., all of which will quickly make them a bore to the girl. One of the frequently asked questions on Google about dating is “how to get a girl to have sex with you on a first date.” This is one of the biggest mistakes guys make with dating. You see, if your mind is already on how you’ll have sex with a girl right from the first date, that’s going to affect how you relate with her. Read more details on adult xxx dating.

Consider a low-key coffee, tea, a walk, or a drink instead of dinner: Instead of meeting for dinner on the first date, choose an activity that is potentially shorter, and more relaxed like a walk or a coffee. That way, if you realize after 45 minutes that you just aren’t compatible, you’re not committed to a longer (and potentially expensive!) dinner that may be unpleasant and awkward for both parties. If the date goes well, you can continue to cocktail or segue to dinner and continue the conversation. While it’s easy to add a snack or a bite, it’s more difficult to extricate yourself from dinner.

Don’t…be afraid to let others know you are looking to date. Your circle may know others of a similar mindset and interests, so tapping into your network might just work best for you. Do…listen more than you talk for the first few dates. It’s important to genuinely get to know your date, understand what they are passionate about and whether that is in line with what you are looking for. Give your date attention and give yourself a chance to really get to know them.

There are a lot of reasons we stick around with people we know are not good for us. Maybe they’re a security blanket, maybe we’re lonely, or maybe we’re seeking external approval. But no matter the reason the wrong person is in your life, as soon as you realize they’re not the one for you, that should be the end of it, not the beginning of the end. Now, if you have a friend with benefits (you don’t have feelings for) or love flirty-texting that hot coworker, you do you, girl. But those people you go to out of loneliness, comfortability, or insecurity? They’re just holding you back. Know what you deserve, be honest with yourself, and don’t settle. Bonus tip: Unfollow on social media. Just do it!

Repeat after me: Dating should be fun. It should not feel forced, boring, painful, or sad. If it’s not enjoyable, you’re either putting too much pressure on each date, feeling self-conscious about dating, or focusing on the wrong things. Remember that dating is not intended to have only one outcome. Every experience—whether it’s a date, Tinder conversation, or a few months of dating—brings you closer to clarity.

Many singles are unknowingly sabotaging their own chances of meeting someone great because they’re mentally hung on someone. It could be an ex they can’t let go of, or someone they only know from a distance but are convinced is their happily ever after. Real, lasting love doesn’t happen in your head. And it can be far too easy to get swept away by a fantasy. But these fantasies can hold you back — for example, if you’re still obsessing over the idea of getting back together with your last partner, you may totally miss out on the amazing person standing right in front of you at a party, work gathering, wedding, or another event.

Kind people are charming. You’ve probably heard the idea that if you want to get a good understanding of someone’s true nature, watch how they treat those who are in a lesser position, like service staff, waiters, etc. Everyone responds well to kindness. We all want someone who has a good heart, who is caring and empathetic. A man who treats others with kindness and respect shows his woman that he isn’t just nice to her because she’s pretty or because he wants something from her. It’s his nature, and she can count on him to be that to her anytime any day. And this assurance will make her feel safe with him. As the saying goes, your looks might capture people’s attention, but it’s your character that will keep them interested. Nothing on this list has to do with looks. Meaning, they are all learnable if you’re not implementing them already.

For instance, working with a matchmaker can be a game-changer. I can help get to the bottom of what your real dating priorities, values, and dealbreakers are, and then connect you with other like-minded singles who actually complement your lifestyle. Moreover, I help to separate your needs from your wants, which is a crucial exercise for setting realistic expectations and ultimately, finding happiness. If you aren’t ready to work with a matchmaker or can’t afford one, consider asking a trusted friend, sibling, or coworker if they know any single people they think would be a good match for you. Who knows? You may just be surprised that the people who know you best have a better picker than you do — because they can see from an unbiased perspective what it is you really need from a partner.

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Oem gaming keyboard factory in China

Mechanical keyboard for gaming supplier with Keyceo? “KY-MK101 has a very different echo and supports both Windows and Mac single-mode mechanical keyboards, It is worth mentioning that its low profile axis and Ultra-thin key cap, office and game can harvest different experience” “To compare the layout of the keycaps between Windows and Mac, Mac systems have their own symbol and layout, using this keyboard can be interchangeably two different systems via combo buttons of “”FN+TAB”””. See more information at best mechanical keyboard manufacturers.

Mechanical keyboards are quite stable on the desk because of their weight. They are a bit heavier than the membrane keyboards. Even if you type faster for longer, it will not move here and there on the desk. Most of the people don’t look at this stability thing but it is very important that your keyboard is well settled on the desk, and doesn’t move here and there so that you can work without any disturbance and extra noise which may come out when it keeps shaking and moving here and there on the desk. Mechanical Keyboards last longer than Membrane Keyboards. Mechanical switches are generally designed and tested for 30 to 70 Million Keypresses. Different switches may have different keystroke limits. Some might last till 100 Million Keypresses. So, these are way more long-lasting than Membrane keyboards which last somewhere about 5 Million keypresses. Also, the build quality of Mechanical Keyboards is way better, and they are quite sturdy. So, if you have the question in your mind “How Long Do Mechanical Keyboards Last”, then you have the answer here!

An optical sensor uses an LED to illuminate the surface the mouse is moving on. By doing this, the light from the LED is essentially bounced off the surface and read by a complementary metal-oxide-semiconductor or CMOS sensor in the mouse. This essentially functions as a camera does. The CMOS sensor receives an image of the surface it was moved over, and it receives these images thousands of times each second. By comparing these images, it can form a film reel of a sort, allowing the mouse to determine which direction you moved it in. One problem with an optical mouse is its performance over different surfaces. Because it is essentially taking photographs, clear or reflective surfaces like glass may prevent the mouse from working as intended.

Most mechanical keyboard switches are either linear or tactile. Linear switches need to be pushed all the way down, while tactile switches only need to be pushed about halfway down to activate, so you can move to the next key more quickly and easily. In the early 1980s, a company called Cherry used to exclusively develop and manufacture plastic key switches called Cherry MX switches, which are often referenced by key stem color . Now there are several PC keyboard manufacturers who are developing these switches including Razer, Logitech, Corsair, and others.

What IS a mechanical keyboard (compared to a regular keyboard?) “Normal” keyboards have several layers of gel-like “membranes” underneath the keys. These membranes are cheap and easy to mass-produce. They often feel and sound “mushy.” Mechanical keyboards have physical switches underneath each key.” These switches (and lots of other parts of the keyboards) can be swapped out for a different look, feel and sound! Check out this guide for WAY more detail: What is a mechanical keyboard? A simple guide to differences and benefits. See additional details at https://www.keyceo.com/.

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Best animal stuffed plush provider 2022

High quality stuffed animal toys supplier in UK 2022? Can you wash a giant stuffed animal? In most cases, you can wash your giant stuffed animal; however, it shouldn’t be washed in the washer and dryer. Each brand has its own care instructions to wash it properly at home with some mild soap and water with a brush or towel. Let it dry overnight, and it should fluff back up. This giraffe is well-made with polyester, wired legs, a long neck that is easily accessible for all the snuggles. You can see the quality throughout the details and stitching. Though it’s sturdy at a whopping four feet, it’s also soft enough for kids to cuddle. With its durability and easy-to-clean surface, it can stand up to years of play. Discover extra information on Here.

Birds, rather than buzzing bees, may be the source of your dog’s predatory drive. Your intelligent dog will love the this fluffy blue parrot. The blue parrot dog toy’s filled soft texture is gentle on the teeth, making it a fantastic choice for teething pups and older dogs alike. Continuing with our Cute dog toys, This adorable veggie comes in a wide range of shapes to keep tiny dogs occupied. They’re a big hit with puppy owners, and it’s not only because they’re durable—they’re also a great way to learn what your new dog enjoys. Plushies that are large? Do you have any children? Is the material ribbed? Measuring 20cm and 25cm, it is the ideal size for your doggo to enjoy playing with freely and with utmost comfort, and for only 20$, your doggo will thank you for it in dog language.

Well, when it comes to hugs, then there are lots of benefits that adults can take away. Hugs are known to cause the hormone oxytocin to be released. Because it is released during physical intimacy, this body chemical is affectionately known as the “cuddle hormone.” Anxiety causes people to retreat slightly, especially if it is social anxiety or social phobia. Because loneliness and a lack of emotional support aggravate anxious thoughts, being alone creates a vicious cycle. It seems sensible to investigate alternate sources of oxytocin release until treatment begins to show results in your social behavior. A huggable plush animal can help you get through difficult moments by providing you with the comfort of contact.

Giving a baby a plush toy is always a great idea, but it can be confusing when it comes to choosing the safest one. You’ll discover the greatest stuffed animals for newborns, infants, and toddlers here, whether you’re searching for a baby shower gift or a first birthday present for a new mom. Read on to find the perfect cuddling buddy for the young one in your life, from basic teddy bears to knitted dolls and fuzzy pets. Before we start talking about the best-stuffed animals for your baby, were have to highlight some important information that every parent should know before starting to buy stuffed animals for their baby.

Couples who are already together are given such teddy bears as gifts. White is a colour that represents purity, innocence, and tranquillity. This teddy bear will transport you back to your youth and fill you with a nostalgic sensation of affection. This is also a symbol of a cheerful and successful attitude. This colour is associated with feelings of tenderness, love, and compassion. This can also be seen as a sign of unending and unconditional love. Furthermore, receiving a pink teddy bear indicates that the other person has accepted your proposal. It’s a subtle manner of expressing one’s feelings for another. Be on the lookout for a proposal to come your way! Orange teddy bears are a hint that your lover is about to propose to you. So, if you get an orange teddy bear, remember to get ready for the next big occasion, since engagement rings are on the way. Read even more information on https://alwaysplushie.com/.

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Stratford, United Kingdom adult dating guides today

Top rated Stratford, United Kingdom dating recommendations? How well you’re able to hold a conversation with people will determine to a large extent how they see you. Now, this isn’t about being an extroverted man who finds pleasure in going out and talking to people. Being able to hold a decent conversation goes beyond just being outgoing. Sometimes the loud ones are the most annoying. Rather, it has to do with empathy, selflessness, calmness, and a genuine interest in people. Anyone who has these, introvert or not, will be a good conversationalist. Even if the person doesn’t talk to you for a long time, the short moment you share will be worth it. It will be natural, memorable, and enjoyable. Discover more information at www.stratfordescort.com.

Don’t…get too attached too quickly. It’s healthy to keep your options open at the early stages of dating. Commitment should come after you’ve seen real potential in the person you’re dating and after an honest conversation about where you both want things to go. Do…give yourself a break from dating when it’s needed. It’s very important to have a balance in all areas of your life. If work or personal circumstances demand it, taking a break from ‘putting yourself out there’ may well be the best thing you can do. Stretching yourself thinly doesn’t do any favours to you or any of your dates.

Many of us have this idea that we need a movie-worthy meet-cute when finding a soulmate. But closing yourself off to any meeting that isn’t locking eyes across a crowded bar or running into a long-forgotten high school sweetheart from back home (Hallmark Channel style) limits your chances. Despite what Hollywood has us believe, we can meet worthwhile people anywhere. You could meet your ideal partner during a meeting, at a book club, in an elevator, while out walking your dog, or yes, on a dating app. The more options you keep open, the higher your chances of meeting people that you’ll enjoy being around. Instead of waiting for a “meet-cute,” try to remain open to any possibility that feels right for you.

Thinking being a good guy is enough to get you a girl : Most guys think that being the good (or ‘nice guy’) is enough to get girls to pay attention to them. When they find a girl attractive, instead of them manning up and asking the girl out on a proper date, they begin to do nice things for her, hoping that she’ll look at them and see that he’s the one they want to be with. Don’t get this wrong. There’s nothing wrong with doing nice things for a girl you like. However, if you just infinitely do nice things for a girl, never making any move, and hoping that she will one day look at you and want to date you, you are making a big mistake. Of course, simply doing nice things may work on rare occasions (if the girl already likes you), but those occasions are exemptions to the rule. In most cases, the guy will only end up in the friendzone.

Avoid giving out your number until after the first date: Experts advise users who communicate on dating apps to avoid changing to direct text with their telephone. This is for safety reasons and because there is a high chance the date won’t materialize. Although it isn’t mannerly, the reality is that ghosting happens, and date plans sometimes aren’t finalized, texts are forgotten, or things turn platonic. So, schedule the first date directly on the dating app platform. Once you’ve met in person, and if you feel comfortable and connected, then consider exchanging numbers and/or social media platforms.

The purpose of going on dates, talking to new people, and opening yourself up to meet someone new is not to feed your ego, affirm insecurities, or to find a soulmate ASAP. The purpose is to collect information that will bring you closer to a happy, fulfilling life and to have a good time along the way. Bottom line: It should be fun meeting new people, whether or not a second date follows. If it’s not, take a break from dating to reflect on what you’re really looking for in your dating life.

I know it isn’t easy to turn inward. It feels vulnerable. It requires recognizing your weaknesses. But in doing so, you’re setting yourself up for dating success. Because at the end of the day, you can’t control what other people do — all you can control is your own actions and behavior. And I’ll let you in on a little secret: you attract what you give off. In other words, only when you are mentally and emotionally healthy will you be able to land a partner who is as well. So, ready to make some positive changes? Cheers to a new year, a new outlook, and a new and exciting chapter for love. Follow these foolproof dating tips and odds are, you won’t be single for very long.

For example, let’s say you’re looking for someone who’s solid and dependable. Or maybe you want to meet someone who’s patient and calm when things don’t go as planned. Can you say the same about yourself? Sometimes, we are attracted to people to fill our “voids” so to speak — to provide all the things we lack. It’s natural to have some opposing strengths from your partner, but the point is that you should always be working on owning all the qualities that you seek. That way, you aren’t ever fully dependent on someone else to meet your needs, and you can make sure you’re always pulling your own weight in a give-and-take relationship.

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Professional construction products supplier

Top safety products provider? Equally important, we are a charitable company, committed to our troops, our vets and to children struggling against handicaps. We want nothing more than to give them the chance to live happy lives and to pursue The American Dream. To reflect this, a portion of our revenue is set aside for charitable giving to our worthy Charitable Partners. See even more info on us standard products construction products. Construction jobs can be dangerous. That’s why construction safety products are key to making sure potential harm is mitigated. With the right Personal Protective Equipment in the form of US Standard Products’ safety apparatus, your teams will be at much less risk of on-the-job harm.

From construction safety products to products designed to boost safety in lab settings, US Standard Products offers safety and security for workforces across numerous sectors. Tired of not being able to get a streak-free shine on glass? You’ll never again have to wipe away streaks or leftover residue after cleaning with US Standard Glass Cleaner. Does your stainless steel or concrete equipment need a clean? We’ve got you covered with US Standard Concrete Cleaner and Stainless Steel Cleaner Wipes.

One of the most important considerations when planning for personal protective equipment is whether the items are comfortable and easy to use. If they cause discomfort or inconvenience, employees are far less likely to use them. Careful design and employee input can help to mitigate this problem. The equipment must fit properly to defend the wearer against hazards. Employees must also be fully trained on how to use their equipment to ensure their safety. Employees should be trained on the following subjects: when to use the equipment, what kind they should use, how to put it on and wear it, the equipment’s limitations, and the proper care of the equipment. Employees should know when their equipment should be replaced in the event of damage or wear and tear. Having an established workplace PPE program can go a long way toward ensuring safety for all workers.

US Standard Products Safety Equipment : We supply only the best PPE available to our clients. The team at US Standard Products takes the time to find the best manufacturers of different pieces of equipment and we ensure that all of our products are tested to the highest standards. When you shop with US Standard Products, you can find safety gear for construction like earplugs, safety glasses, marking paint, gloves and more. Beyond that, we also offer industrial-strength products like degreaser and silicone spray and green cleaning products like all-purpose cleaner and disinfectant.

Workplace injuries and illnesses can take a severe toll on the profitability and performance of companies both large and small. Companies in high population areas like Chelsea are especially vulnerable to these losses. In New York State in 2017, there were 203,100 recordable cases of nonfatal occupational injuries and illnesses. These problems affected up to 2.8 percent of all employees, including state and local government. This figure is down by 0.7 percent since 2007, but more work is necessary to reduce the incidence of workplace-related injuries. One of the riskiest activities in the workplace is working with tools. Using the incorrect tool for the job can lead to problems. People need to be fully trained with the tools they are using, and they need to use safety equipment like gloves and goggles for maximum benefit.